1982 - 1987   Ph.D. in the field of molecular biology, Dept of Biology, Massachusetts Institute of Technology, Massachusetts, U.S.A. (Thesis advisors: U.L. RajBhandary and G. Khorana)
1977 - 1979 MS in biological science, Dept of Biological Science, Korea Advanced Institute of Science and Technology, Seoul, KOREA
1973 - 1977 BS in pharmaceutical chemistry, Dept of Pharmaceutical Chemistry, College of Pharmacy, Seoul, National University, Seoul,

1999 - Present : Deputy Director General, International Biographical Center, Cambridge, England
1998 - Present : Associate Professor, Department of Biotechnology, College of Engineering , Yonsei University
1996 - 1998 : Board of Directors, Hanil Group
1993 - 1997 : Director, Institute of Biological Sciences, Hanhyo Institutes of Technology, KOREA
1992 - 1993 : Research Scientist, Aviron, Mountain View, California, USA
1988 - 1992 : Postdoctoral research assistant with Professor George G. Brownlee, Sir William Dunn School of Pathology, University of Oxford, UK
1988 - 1988 : Postdoctoral Research Associate with Professor U.L. RajBhandary, Dept of Biology, Massachusetts Institute of  Technology, Cambridge, Massachusetts, USA
1983 - 1986 : Teaching Assistant at the Dept of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
1983 - 1983 : Research Assistant, Biogen, Cambridge, Massachusetts, USA
1979 - 1982 : Research Scientist at the Korea Institute of Science and Technology, Seoul, KOREA

Applied Biochemistry and Molecular Virology. Specific areas of interest include:

1. Regulation of replication and transcription of influenza virus.         
   
2. Development of live attenuated influenza vaccine.
   
3. Development of therapeutic vaccine for hepatitis and cancer.
   
4. tRNA engineering in regulation of translational initiation.
   
5. Molecular modeling, rational drug design against hepatitis C virus and hepatitis B virus.
   
6. Design of prokaryotic and eukaryotic expression vectors.
   

1. H-K Cheong, C. Cheong, Y.S.  Lee, B.L. Seong, and B-S Choi  (1999) Three dimensional structure of the panhandle  RNA of influenza virus A studied by NMR spectroscopy.  Nucl. Acids Res. 27, 1392-1397.
   
2. S.W. Lee, J.W. Youn, B.L. Seong and Y.C. Sung (1999) IL-6 induces long-term protective immunity against a lethal challenge of influenza virus.  Vaccine 17, 490-496
   
3. K.H. Lee and B.L. Seong (1998) The position 4 nucleotide at the 3'-end of the influenza virion RNA is involved in temporal regulation of  transcription and replication of influenza RNAs and affects the repertoire of influenza surface  antigens.  J. Gen. Virol. 78, 1923.
   
4. Y.S. Lee and B.L. Seong.(1998). Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses.  J. Gen. Virol.  79, 673.
   
5. C.S. Bae, D.S. Yang, K.R. Chang, B.L. Seong and J. Lee (1998). Enhanced secretion of human granulocyte colony-stimulating factor directed by a novel hybrid fusion peptide from recombinant Saccharomyces cerevisiae at high cell concentration.  Biotechnol. Bioeng.  57, 600
   
6. K.R. Chang, J.W. Moon, J. Lee, C.S. Bae, D.S. Yang, and B.L. Seong , Novel secretion system of recombinant Saccharomyces cerevisiae  using the N-terminus of human interleukin-1b as secretion enhancer.  Biotechnol. Prog. submitted
   
7. H.J. Kim, E. Fodor, G.G. Brownlee and B.L. Seong (1997) Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo. J.Gen.Virol. 78, 353-357.
   

MORE

BACK